Hairy cell leukemia statistics

It is characterized by pancytopenia, splenomegaly, bone marrow fibrosis, and presence of atypical lymphoid cells with hairy projections in peripheral blood, bone marrow and spleen. HCL is potentially curable and treatment with purine analog cladribine induces complete remission CR. The clinical features, laboratory parameters, bone marrow findings, cytochemistry, immunophenotyping, and outcome with treatment were studied. Results: Among 8 cases of HCL who were treated with cladribine, 7 achieved remission and 1 succumbed to infection during course of treatment.

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Treating Hairy Cell Leukemia

Lymphoma Action | Hairy cell leukaemia

Hairy cell leukemia cells, which appear as the darker cells in this photo, are surrounded by a halo of fine projections villi. To diagnose hairy cell leukemia, your doctor may take a sample of bone marrow from your body and examine it under a microscope to look for hairy cells. Hairy cell leukemia is a rare, slow-growing cancer of the blood in which your bone marrow makes too many B cells lymphocytes , a type of white blood cell that fights infection. These excess B cells are abnormal and look "hairy" under a microscope. As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced. Hairy cell leukemia affects more men than women, and it occurs most commonly in middle-aged or older adults.
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Update on Hairy Cell Leukemia

The standard first-line treatment, which has remained unchanged for the past 25 to 30 years, is single-agent therapy with a purine analogue, either cladribine or pentostatin. This approach produces a high rate of complete remission. Residual traces of HCL cells, referred to as minimal residual disease, are present in most patients and cause frequent relapse. Repeated treatment with a purine analogue can restore remission, but at decreasing rates and with increasing cumulative toxicity. Rituximab has limited activity as a single agent but achieves high complete remission rates without minimal residual disease when combined with purine analogues, albeit with chemotherapy-associated toxicity.
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Hairy cell leukemia HCL tends to be slow growing. Patients without symptoms often don't need to be treated right away, but they do need to be watched carefully. Doctor visits are done every few months to check for signs that the HCL is growing and to see if it's causing any problems like low blood counts, fatigue, or an enlarged spleen.
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